![]() These TE-derived regulatory mechanisms also tend to function in a tissue-specific fashion. Moreover, both TE-derived cis-regulatory sequences and TE-derived regulatory RNAs have been implicated in providing evolutionary novelty to gene regulation. TEs thus provide crucial regulatory roles by being part of cis-regulatory and regulatory RNA sequences. Furthermore, TEs sequences were found to be critical for regulatory functions of these RNAs, including binding to the target mRNA. Second, TEs encode for regulatory RNAs with their sequences showed to be present in a substantial fraction of miRNAs and long non-coding RNAs (lncRNAs), indicating the TE origin of these RNAs. TE-derived cis-regulatory sites are found in promoter and enhancer elements, providing binding sites for a wide range of trans-acting factors. First, TEs provide cis-regulatory sequences in the genome with their intrinsic regulatory properties for their own expression, making them potential factors for regulating the expression of the host genes. There are two known principal ways by which TEs regulate the expression of genes. As one of their important functional impacts on gene function and genome evolution, TEs participate in regulating the expression of genes nearby and even far away at transcriptional and post-transcriptional levels. ISBN 0-13-081908-5.Transposable elements (TEs), also known as mobile elements (MEs), are interspersed repeats that constitute a major fraction of the genomes of higher organisms. Upper Saddle River, NJ: Prentice Hall PTR. ![]() ![]() Bioprocess Engineering: Basic Concepts (2nd ed.), p. 220. Microbiology and Molecular Biology Reviews.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |